Tissue specific viral vectors

Details Tissue specific viral vectors Tissue specific viral vectors

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 9/64 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2222457

Host cell specific adenovirus vehicles are provided for transfecting target host cells. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia.

L'invention concerne des adénovirus vecteurs spécifiques à des cellules hôtes, pour transfecter des cellules hôtes cibles. La réplication du virus est limitée aux cellules cibles en assurant une régulation de l'initiation de la transcription, basée sur le fait que les facteurs de transcription ne deviennent actifs que dans certains types cellulaires spécifiques et limités. L'adénovirus modifié peut être utilisé comme vecteur pour conférer de nouvelles caractéristiques génétiques, en particulier de nature cytotoxique, permettant de traiter des néoplasies.

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