Titanium catalyzed preparation of carbapenem intermediates

C - Chemistry – Metallurgy – 07 – D

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C07D 477/14 (2006.01) C07D 205/08 (2006.01) C07D 477/04 (2006.01)

Patent

CA 2328219

An efficient method for the synthesis of a compound of formula (2) is disclosed which comprises reacting a 4-acyl-2-azetidinone with a titanium, zirconium or hafnium enolate of a 1-hydroxy-2-butanone derivative.

L'invention concerne un procédé efficace de synthèse d'un composé de formule (2), consistant à faire réagir une 4-acyl-2-azétidone avec un énolate de titane, zirconium ou hafnium d'un dérivé de 1-hydroxy-2-butanone.

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