Tkts as modifiers of the beta-catenin pathway and methods of...

Details Tkts as modifiers of the beta-catenin pathway and methods of... Tkts as modifiers of the beta-catenin pathway and methods of...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2513601

Human TKT genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta- catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of TKT are provided.

Des gènes humains des transcétolases sont identifiés comme modulateurs du chemin de la bêta-cathénine. Ils constituent donc des cibles thérapeutiques pour des troubles associés à une déficience de la fonction bêta-cathénine. L'invention concerne ainsi des procédés permettant d'identifier des modulateurs de la bêta-caténine, par recherche systématique d'agents qui modulent l'activité de la transcétolase.

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