Tlr 7 ligand and uses thereof

Details Tlr 7 ligand and uses thereof Tlr 7 ligand and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/117 (2010.01)

Patent

CA 2744346

The present invention provides a TLR7 ligand and its use in therapeutic applications. Specifically, the present application provides a RNA oligonucleotide comprising a G:U wobble base pair in the context of a fully double-stranded structure and its use in treating disease such as viral infections, immune disorders and cancer.

La présente invention concerne un ligand du TLR7 et son utilisation dans des applications thérapeutiques. De manière spécifique, la présente demande concerne un oligonucléotide d'ARN comprenant une paire de bases de type Wobble G:U dans le contexte d'une structure totalement double brin et de son utilisation dans le traitement de maladies telles que des infections virales, des troubles immuns et le cancer.

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