Tlr/cd14 binding inhibitor

Details Tlr/cd14 binding inhibitor Tlr/cd14 binding inhibitor

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A61K 38/02 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 31/04 (2006.01) A61P 43/00 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2404511

An anti-CD14 antibody having a function of inhibiting the binding of CD14 to Toll like receptor (TLR) and its fragment; a hybridoma producing this antibody or its fragment; a process for producing a peptide or the antibody; a CD14 modification polypeptide; a method of screening a remedy for sepsis; and medicinal compositions for sepsis.

L'invention concerne un anticorps anti-CD14 ayant une fonction d'inhibition de la liaison de CD14 au récepteur de type Toll (TLR), ainsi que les fragments dudit anticorps. L'invention concerne également un hybridome produisant ledit anticorps ou ses fragments ; un procédé de fabrication d'un peptide ou de l'anticorps ; un polypeptide de modification de CD14 ; un procédé de criblage d'un remède contre la sepsie, et des compositions médicales contre la sepsie.

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