Tnf-a antagonist multi-target binding proteins

Details Tnf-a antagonist multi-target binding proteins Tnf-a antagonist multi-target binding proteins

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C07K 16/46 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2729749

This disclosure provides a multi-target fusion protein composed of a TNF- .alpha. antagonist domain and another binding domain antagonistic for a heterologous target, such as IL6, RANKL, IL7, IL17A/F, TWEAK, CSF2, IGF1, IGF2 or BLyS/APRIL, or agonistic for a heterologous target, such as IL10. The multi- specific fusion protein may also include an intervening domain that separates the binding domains and allows for dimerization. This disclosure also provides polynucleotides encod-ing the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.

Cette invention concerne une protéine hybride multi-cible constituée dun domaine antagoniste du TNF-a et dun autre domaine de liaison antagoniste dune cible hétérologue, par exemple IL6, RANKL, IL7, IL17A/F, TWEAK, CSF2, IGF1, IGF2 ou BLyS/APRIL, ou agoniste dune cible hétérologue, par exemple IL10. La protéine hybride multi-spécifique peut également contenir un domaine interposé séparant les domaines de liaison et permettant la dimérisation. Cette invention concerne aussi des polynucléotides codant les protéines hybrides multi-spécifiques, des compositions constituées des protéines hybrides, et des procédés dutilisation des protéines hybrides multi-spécifiques et des compositions.

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