G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01) A61K 31/40 (2006.01) A61P 35/00 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2686638
TNF.alpha. gene expression can be used as a biomarker of a cell's sensitivity to antagonists of inhibitor of apoptosis proteins (IAPs). Methods of the invention are useful for screening patients to identify those who could benefit from administration of an IAP antagonist to treat various malignant or benign tumors, benign proliferative diseases, or autoimmune diseases.
Selon l'invention, l'expression du gène TNF.alpha. peut être utilisée en tant que bio-marqueur de la sensibilité d'une cellule aux antagonistes d'un inhibiteur des protéines de l'apoptose (Inhibitor of Apoptosis Proteins : IAP). L'invention concerne des procédés utiles pour dépister parmi les patients ceux chez qui l'administration d'un antagoniste des IAP serait bénéfique pour traiter diverses tumeurs malignes ou bénignes, des maladies prolifératives bénignes ou des maladies auto-immunes.
Alavi Alireza
Chunduru Srinivas K.
Mckinlay Mark A.
Silke John
Vaux David
Goudreau Gage Dubuc
La Trobe University
Tetralogic Pharmaceuticals Corp.
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