Tnf-.alpha. inhibitor

Details Tnf-.alpha. inhibitor Tnf-.alpha. inhibitor

A - Human Necessities

61

K

A61K 31/47 (2006.01) A61K 31/4704 (2006.01)

Patent

CA 2209555

A method for the propylaxis and treatment of diseases induced by accelerated INF-.alpha. secretion, such as rheumatoid arthritis, endotoxin shock, adult respiratory distress syndrome, thermal burn, asthma, myocardial infarction, acute phase of viral myocardiosis, etc. which comprises administering a carbostyril compound of formula (I) wherein R1 is H or lower alkyl, and R2 is phenyl(lower)alkyl having optionally 1 to 3 lower alkoxy substituents on the phenyl ring, or a pharmaceutically acceptable salt thereof to a subject.

L'invention porte sur une méthode prophylactique et de traitement de maladies induites par une sécrétion accélérée du TNF-.alpha., telles que la polyarthrite rhumatoïde, le choc endotoxique, le syndrome de détresse respiratoire de l'adulte, la brûlure thermique, l'asthme, l'infarctus du myocarde, la phase aiguë de la myocardose virale, etc. Cette méthode consiste à administrer à un patient un composé, ou un sel de celui-ci, acceptable du point de vue pharmaceutique, à base de carbostyril de la formule (I) dans laquelle R?1¿ représente hydrogène ou alkyle inférieur et R?2¿ représente alkyle (inférieur) phényle avec, éventuellement de 1 à 3 substituants alcoxy inférieur sur le cycle phénylique.

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