Tnf-alpha muteins and a process for preparing them

Details Tnf-alpha muteins and a process for preparing them Tnf-alpha muteins and a process for preparing them

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A61K 35/12 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 14/525 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2155103

The invention relates to a tumor necrosis factor mutein characterized in that the TNF-.alpha. amino acid sequence is mutated, or deleted totally or partially, in the region extending from amino acid position at 101 to 116 in such a way that: either the lectin-like activities are modulated with respect to INF-.alpha., and/or the toxic activity is reduced with respect to TNF-.alpha., and/or the inflammatory cytokines inducing capacities are modulated with respect to TNF-.alpha., and/or the adhesion molecules inducing capacities are modulated with respect to TNF-.alpha., and/or the metastasis promoting activity is reduced with respect to TNF-.alpha., and/or the half life time is increased with respect to INF-.alpha. and with said muteins being characterized in that they have retained the aforementioned activities; or a pharmaceutically acceptable salt thereof.

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