Tnf antagonists

Details Tnf antagonists Tnf antagonists

C - Chemistry, Metallurgy

07

K

C07K 14/525 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) C07K 14/47 (2006.01) C07K 14/715 (2006.01) C12N 15/62 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2587948

TNF binding polypeptides based on human tetranectin C-type lectin like domains (CTLD) with improved binding characteristics and improved efficacy. The polypeptides comprise a TNF binding domain having the amino acid sequence KRWSRYF (SEQ ID NO:1). Also provided are methods of preparing the polypeptides of the invention. The polypeptides may be used for the preparation of pharmaceutical compositions, and for treatment of a subject having a pathology mediated by TNF, such as treatment of rheumatoid arthritis.

La présente invention a pour objet des polypeptides se liant au TNF basés sur les domaines de reconnaissance de lectine de type C (CTLD) de la tétranectine humaine. Lesdits polypeptides présentent des caractéristiques de liaison et d'efficacité améliorées. Lesdits polypeptides comprennent un domaine liant le TNF dont la séquence d'acides aminés est KRWSRYF (SEQ ID NO:1). La présente invention a également pour objet des méthodes d'élaboration desdits polypeptides. Lesdits polypeptides peuvent être employés dans la mise au point de préparations pharmaceutiques, et dans le traitement d~un sujet atteint d~une pathologie due au TNF, tel que le traitement de la polyarthrite rhumatoïde.

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