Tnf-beta-like protein for treating prostate cancer, and...

Details Tnf-beta-like protein for treating prostate cancer, and... Tnf-beta-like protein for treating prostate cancer, and...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) C07K 14/495 (2006.01) C12N 15/18 (2006.01)

Patent

CA 2265444

This invention provides proteins which selectively inhibit the proliferation of androgen-independent prostate cancer cells. This invention also provides a nucleic acid molecule encoding the instant proteins, including a nucleic acid molecule suitable for use in gene therapy for treating a subject afflicted with androgen-independent prostate cancer. This invention further provides a composition of matter which selectively kills androgen-independent prostate cancer cells, and comprises the instant proteins and a toxic moiety operably affixed thereto. Finally, the instant invention provides related pharmaceutical compositions and methods for treating androgen-independent prostate cancer.

Cette invention a trait à des protéines inhibant, de manière sélective, la prolifération de cellules du cancer de la prostate, ce type de cancer n'étant pas lié aux androgènes. Cette invention concerne également une molécule d'acide nucléique codant lesdites protéines, y compris une molécule d'acide nucléique convenant à une thérapie génique visant à traiter un sujet atteint d'un cancer de la prostate du type non lié aux androgènes. Elle concerne, de surcroît, une composition à base d'une substance tuant, de manière sélective, des cellules du cancer de la prostate de ce type, cette composition comportant les protéines susmentionnées ainsi qu'une fraction toxique fixée de manière opérationnelle à ces protéines. Cette invention porte enfin sur des compositions connexes à usage pharmaceutique ainsi que sur des méthodes thérapeutiques visant à traiter un cancer de la prostate non lié aux androgènes.

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