A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/19 (2006.01) A61P 7/10 (2006.01) A61P 11/00 (2006.01) C07K 14/525 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2334941
The present invention relates to the finding that peptides derived from a specific domain of tumor necrosis factor-alpha (TNF-.alpha.) can efficiently be used to treat oedema. More specifically, the present invention relates to the usage of peptides derived from the region of human TNF-.alpha. from Ser100 to Glu116 to treat pulmonary oedema. Moreover, the present invention concerns a circularized peptide having amino acid sequence CGQRETPEGAEAKPWYC which is very efficient in inducing oedema resorption.
Cette invention se rapporte à la découverte selon laquelle des peptides dérivés d'un domaine spécifique du facteur de nécrose tumorale alpha (TNF-.alpha.) peuvent être utilisés efficacement pour traiter les oedèmes. Cette invention se rapporte plus spécifiquement à l'utilisation de peptides dérivés de la région du TNF-.alpha. humain comprise entre Ser?100¿ et Glu?116¿ pour traiter les oedèmes pulmonaires. Cette invention présente en outre un peptide circularisé ayant la séquence d'acides aminés CGQRETPEGAEAKPWYC qui est très efficace pour induire la résorption des oedèmes.
Bloc Alain
de Baetselier Patrick
Fransen Lucie
Lucas Rudolf
Pugin Jerome
Innogenetics N.v.
Lucas Rudolf
Smart & Biggar
LandOfFree
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