C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/16 (2006.01) A61K 51/10 (2006.01) A61P 9/10 (2006.01) A61P 17/02 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2583677
The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
L'invention porte sur un récepteur TWEAK et sur des procédés d'identification et d'utilisation d'agonistes et d'antagonistes du récepteur TWEAK. Plus précisément, l'invention concerne des procédés de criblage d'agonistes et d'antagonistes et de traitement de maladies ou de conditions provoquées par angiogenèse, telles que des tumeurs solides ou des déficiences vasculaires du tissu cardiaque ou périphérique.
Fanslow William C. III
Ketchem Randal R.
Kim Kristine M.
Wiley Steven R.
Immunex Corporation
Smart & Biggar
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