C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/28 (2006.01) A61K 38/19 (2006.01) C07K 14/525 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2055168
RAN 4105/136 Abstract It is an object of the present invention to provide a human Tumor Necrosis Factor mutein or a pharmaceutically acceptable salt thereof characterized in that the TNF sequence is changed by deletion, insertion and/or substitution of one or more amino acids so that the mutein shows a significant difference between its binding affinity to the human p75-Tumor-Necrosis-Factor-Receptor and to the human p55-Tumor-Necrosis-Factor-Receptor, DNA sequences coding for such muteins, vectors comprising such DNA sequences, host cells trans- formed with such vectors and a process for the production of such muteins employing such transformed host cells and pharmaceutical compositions containing such muteins and their use for the treatment of illnesses, e.g. cancer.
Fiers Walter
Tavernier Jan
Van Ostade Xaveer
Gowling Lafleur Henderson Llp
Hoffmann-La Roche (f.) Ag
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