Tnf superfamily collectin fusion proteins

Details Tnf superfamily collectin fusion proteins Tnf superfamily collectin fusion proteins

C - Chemistry, Metallurgy

07

K

C07K 14/525 (2006.01) A61K 38/19 (2006.01) C12N 5/10 (2006.01) C12N 15/28 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2692802

The present invention refers to a fusion protein comprising a TNF- superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin trimerization domain, to a nucleic acid molecule encoding the fusion protein, and to a cell comprising the nucleic acid molecule. The fusion protein is present as a trimeric complex or as an oligomer thereof. The fusion protein, the nucleic acid, and the cell is suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications.

La présente invention concerne une protéine de fusion comprenant une cytokine de la superfamille des TNF (TNFSF) ou un domaine se liant au récepteur de celle-ci fusionné à un domaine de trimérisation des collectines, une molécule d'acide nucléique codant pour la protéine de fusion, et une cellule comprenant la molécule d'acide nucléique. La protéine de fusion est présente sous la forme d'un complexe trimère ou sous la forme d'un oligomère de celui-ci. La protéine de fusion, l'acide nucléique, et la cellule est appropriée en tant que composition pharmaceutique ou pour des applications thérapeutiques, diagnostiques et/ou de recherche.

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