C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/01 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C12N 15/62 (2006.01) A61K 38/16 (2006.01)
Patent
CA 2661599
The present invention refers to fusion proteins comprising a TNF superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a trimerization domain and a nucleic acid molecule encoding the fusion protein. The fusion protein is present as a trimeric complex or as an oligomer thereof and is suitable for therapeutic, diagnostic and/or research applications.
L'invention concerne des protéines de fusion comprenant une cytokine de la superfamille TNF (TNFSF) ou un domaine de liaison au récepteur de celui-ci fusionné à un domaine de trimérisation et une molécule d'acide nucléique codant la protéine de fusion. Ladite protéine de fusion, qui est présente comme complexe trimère ou comme oligomère de celui-ci, est appropriée dans des applications thérapeutiques, de diagnostic et/ou de recherche.
Gieffers Christian
Hill Oliver
Thiemann Meinolf
Apogenix Gmbh
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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