Tocopherol associated protein and uses thereof

Details Tocopherol associated protein and uses thereof Tocopherol associated protein and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2482909

The present invention provides a novel tocopherol associated protein (TAP-38) DNA/protein with a (76) nucleotide base deletion resulting in a (25) amino acid deletion, followed by (90) novel nucleotides that code for (30) novel amino acids that are not expressed by TAP-46. The present invention provides data showing that TAP-38 enhances the apoptotic inducing properties of tocopherol based compounds, and blockage of TAP reduces the effectiveness of tocopherol based compounds. Thus, the present invention claim that expression of TAP-38 by tumor cells enhances the apoptotic inducing properties of tocopherol based compounds. The present invention provides aerosol liposome/transfection/infection methods for delivery of TAP-38 and TAP-46 cDNA plasmids separately and in combination with tocopherol based apoptotic inducing agents as well as with other chemotherapeutic agents as a method for treatment and prevention of cellular proliferative diseases and disorders.

L'invention concerne un nouvel ADN de protéine associée au tocophérol (TAP-38)/protéine associée au tocophérol (TAP-38) avec une délétion de 76 bases nucléotidiques ayant pour résultat une délétion de 25 acides aminés, suivie de 90 nouveaux nucléotides qui codent pour 30 nouveaux acides aminés non exprimés par TAP-46. L'invention fournit des données montrant que TAP-38 renforce les propriétés d'induction apoptotiques de composés à base de tocophérol, et que le blocage de TAP diminue l'efficacité de composés à base de tocophérol. Par conséquent, cette invention affirme que l'expression de TAP-38 par des cellules tumorales renforce les propriétés d'induction apoptotiques de composés à base de tocophérol. Cette invention concerne également des méthodes de transfection/infection par aérosol de liposome pour l'administration de plasmides d'ADNc de TAP-46 et de TAP-38 séparément et combinés à des agents d'induction apoptotiques ainsi qu'à d'autres agents chimiothérapeutiques en tant que méthode de traitement et de prévention de maladies et troubles prolifératifs cellulaires.

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