C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/72 (2006.01) A61K 31/355 (2006.01) A61P 25/28 (2006.01) C07D 311/58 (2006.01) C07D 313/08 (2006.01)
Patent
CA 2536791
The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula (I), which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia and/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula (I).
La présente invention concerne tout composé isolé ou synthétique et en particulier les composés de formule (I), capables de moduler la spécification cellulaire des cellules souches neurales, de favoriser la différenciation puis la survie des neurones et cellules gliales en différenciation ainsi que la différenciation de cellules précurseurs d~oligodendrocytes en oligodendrocytes matures. Les composés selon l~invention sont par ailleurs capables de diminuer la composante inflammatoire lors de maladies affectant le système nerveux notamment en diminuant l~activation de la micrologie et/ou des astrocytes et/ou en diminuant la gliose réactionnelle. L~invention concerne également les méthodes de préparation de tels composés ainsi que l~utilisation des dits composés dans le cadre de la préparation d~une composition pharmaceutique destinée à la prévention ou au traitement de maladies affectant le système nerveux. Les composés de l~invention répondent plus particulièrement à la formule générale (I).
Heuschling Paul
Luu Bang
Morga Eleonora
Muller Thierry
Centre National de La Recherche Scientifique
Gowling Lafleur Henderson Llp
Universite Du Luxembourg
Universite Louis Pasteur
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