C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/04 (2006.01) A61K 31/355 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 311/58 (2006.01) C07D 311/66 (2006.01) C07D 311/72 (2006.01)
Patent
CA 2345079
The present invention provides an antiproliferative compound having structural formula (I), wherein X is oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers and nitriles; R2 is hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R3 is selected from the group consisting of hydrogen, methyl, benzyl carboxylic acid, benzyl carboxilate, benzyl carboxamide, benzylester, saccharide and amine; R4 is of methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; and R5 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxyl, amide and ester. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.
L'invention concerne un composé antiprolifératif représenté par la formule (I): dans laquelle X représente oxygène, azote ou soufre; R?1¿ représente alkyle, alkényle, alkynyle, aryle, hétéroaryle, acide carboxylique, carboxylate, carboxamide, ester, thioamide, thiolacide, thiolester, saccharide, saccharide possédant une liaison avec alkoxy, amine, sulfonate, sulfate, phosphate, alcool, éthers et nitriles; R?2¿ représente hydrogène, méthyle, acide benzylcarboxylique, benzylcarboxylate, benzylcarboxamide, benzylester, saccharide et amine; R?3¿ est sélectionné dans le groupe constitué par hydrogène, méthyle, acide benzylcarboxylique, benzylcarboxylate, benzylcarboxamide, benzylester, saccharide et amine; R?4¿ représente méthyle, acide benzylcarboxylique, benzylcarboxylate, benzylcarboxamide, benzylester, saccharide et amine; R?5¿ représente alkyle, alkényle, alkynyle, aryle, hétéroaryle, carboxyle, amide et ester. Elle concerne également un procédé servant à induire l'apoptose dans une cellule et consistant à administrer une composition contenant un composé.
Gardner Robb
Hurley Laurence
Israel Karen
Kline Kimberly
Liu Shengquan
Borden Ladner Gervais Llp
Research Development Foundation
LandOfFree
Tocopherols, tocotrienols, other chroman and side chain... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tocopherols, tocotrienols, other chroman and side chain..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tocopherols, tocotrienols, other chroman and side chain... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1839303