Tocotrienols in the treatment of hypercholesterolemia,...

A - Human Necessities – 61 – K

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A61K 31/35 (2006.01) A61K 31/355 (2006.01) C07D 311/72 (2006.01)

Patent

CA 2026713

ABSTRACT This invention relates to the use of tocotrienol, gamma-tocotrienol and delta-tocotrienol in reducing hypercholesterolemia, hyperlipidemia and thromboembolic disorders in mammals. The isolation of these tocotrienols from natural sources and their chemical synthesis is disclosed. The present invention also relates to prodrugs and pharmaceutical compositions of gamma-tocotrienol, delta-tocotrienol and tocotrienol and uses thereof.

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