Tolerance to natural antibody antigens

Details Tolerance to natural antibody antigens Tolerance to natural antibody antigens

A - Human Necessities

01

N

A01N 63/00 (2006.01) A01K 67/027 (2006.01) A01N 43/04 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 16/18 (2006.01) C07K 16/42 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 9/10 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2279542

Methods of inducing tolerance in a recipient mammal to an antigen or to a graft which expresses the antigen. The methods typically include providing a cell from the recipient mammal which presents the antigen, and allowing the cell to produce or display the moiety in the recipient mammal, thereby inducing tolerance to the antigen.

L'invention concerne des procédés destinés à induire une tolérance, chez un mammifère récepteur, à un antigène ou à une greffe exprimant l'antigène. Ces procédés comportent de façon caractéristique les étapes consistant à obtenir une cellule du mammifère récepteur qui présente l'antigène, et laisser la cellule produire ou présenter la fraction chez le mammifère récepteur, ce qui permet d'induire une tolérance à l'antigène.

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