Toll-like receptor 14 (tlr14 ) and use thereof

Details Toll-like receptor 14 (tlr14 ) and use thereof Toll-like receptor 14 (tlr14 ) and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/20 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) A61P 37/02 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2604515

An isolated polypeptide comprises an amino acid sequence of SEQ ID No. 1 or 2 or a variant or fragment thereof. The variant may comprise an amino acid sequence that is at least 70% or 95% identical to the amino acid sequence of SEQ ID No. 1 or 2. A fragment thereof may be a peptide comprising at least 12 contiguous amino acids of SEQ ID No. 1 or 2. The polypeptide exhibits toll- like receptor activity. The TLR has been named TLRl 4. TLR receptors recognise a range of ligands and activate a series of signalling pathways that lead to the induction of immune and inflammatory genes.

L'invention concerne un polypeptide isolé comprenant une séquence d'acides aminés de SEQ ID No. 1 ou 2 ou un variant ou un fragment de celles-ci. Le variant peut contenir une séquence d'acides aminés qui est identique à raison d'au moins 70 % ou 95 % à la séquence d'acides aminés de SEQ ID No. 1 ou 2. Le fragment de ce polypeptide peut être constitué d'un peptide comprenant au moins 12 acides aminés contigus de SEQ ID No. 1 ou 2. Ce polypeptide présente une activité de récepteur de type Toll (TLR: Toll-like receptor). Ce TLR a été dénommé TLRl 4. Ces récepteurs TLR reconnaissent un large éventail de ligands et activent une série de voies de signalisation qui conduisent à l'induction de gènes de réponse immunitaire et de réponse inflammatoire.

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