C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2125298
97 A B S T R A C T Novel Tools for the Diagnosis and Treatment of Alzheimer's disease The invention relates to epitopes of the tau protein which are specifically occurring in a phosphorylated state in tau protein from Alzheimer paired helical filaments, to protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to pharmaceutical compositions for the treatment or prevention of Alzheimer's disease, to diagno- stic compositions and methods for the detection of Alzhei- mer's disease and to the use of said epitopes for the gene- ration of antibodies specifically detecting Alzheimer tau protein. Additionally, the invention relates to methods for testing drugs effective in dissolving Alzheimer paired heli- cal filaments or preventing the formation thereof.
Biernat Jacek
Drewes Gerard
Lichtenberg-Kraag Birgit
Mandelkow Eckard
Mandelkow Eva-Maria
Blake Cassels & Graydon Llp
Max Planck Gesellschaft Zur Forderung Der Wissenschaften E.v.
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