Topical administration of toremifene and its metabolites

Details Topical administration of toremifene and its metabolites Topical administration of toremifene and its metabolites

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/70 (2006.01) A61K 31/135 (2006.01)

Patent

CA 2133429

Topical preparations containing as active ingredient toremifene or one of its metabolites N-demethyltoremifene or 4-hydroxy-toremifene or their pharmaceutically acceptable non-toxic salts are useful for the treatment of cancers localized in the skin or on a short distance from the skin such as metastatic lesions of breast cancer. They may also be used in adjuvant therapy of breast cancer and in the reversal of multidrug resistance of cancer cells to cytotoxic drugs. Such topical preparations are of particular interest in the treatment of melanoma, lymphoma, Kaposi's sarcoma and fungoides mycosis.

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