Topical antiglaucoma compositions comprising carbonic...

Details Topical antiglaucoma compositions comprising carbonic... Topical antiglaucoma compositions comprising carbonic...

A - Human Necessities

61

K

A61K 31/54 (2006.01) A61K 31/33 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2129037

Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and ocular hypertension are described. The compositions comprise a combination of a beta-blocker and a carbonic anhydrase inhibitor to reduce the production of aqueous humor, preferably formulated as a suspension having a pH between about 6.8 and about 7.8. These compositions may additionally contain a mucomimetic anionic polymer and/or a finely-divided drug carrier substrate to provide sustained release. A method of controlling elevated intraocular pressure with these compositions is also described.

Composés pharmaceutiques ophtalmiques utiles pour contrôler la tension intraoculaire élevée associée au glaucome et à l'hypertension oculaire. Les composés comprennent la combinaison d'un béta-bloquant et d'un inhibiteur anhydrase carbonique pour réduire la production d'humeur aqueuse, combinaison qui constitue de préférence une suspension dont le pH varie entre 6,8 et 7,8 environ. Ces composés peuvent également contenir un polymère anionique mucomimétique et/ou un substrat vecteur de médicament finement divisé pour offrir une libération prolongée. Une méthode de contrôle de la pression intraoculaire élevée au moyen de ces composés est également divulguée.

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