Topical avermectin formulations and methods for elimination...

Details Topical avermectin formulations and methods for elimination... Topical avermectin formulations and methods for elimination...

A - Human Necessities

61

K

A61K 31/7048 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/24 (2006.01) A61K 47/46 (2006.01) A61P 33/14 (2006.01)

Patent

CA 2666365

An avermectin-based topical formulation is disclosed which is useful for prevention and treatment of head lice (Pediculus humanus capitis). This topical formulation may be formulated as a shampoo-condition which comprises an effective amount of avermectin, solubilizers, suspending agents, preservatives, non-ionic surfactants, humectants, a silicone compound, and water. Also disclosed are methods of using the topical formulations disclosed within this specification to treat either a susceptible or treatment- resistant strain of lice, as well as uses in the manufacture of a medicament for treating or preventing a lice infestation from a susceptible or treatment-resistant strain in a human patient.

L'invention concerne une formulation topique à base d'avermectine qui s'utilise pour la prévention et le traitement des poux (Pediculus humanus capitis). Cette formulation topique peut être formulée comme un shampooing-revitalisant qui comporte une quantité efficace d'avermectine, des solubilisants, des agents suspenseurs, des conservateurs, des agents tensioactifs non ioniques, des humectants, un composé de silicone et de l'eau. Des procédés d'utilisation des formulations topiques décrites dans ce mémoire sont également décrits pour traiter une souche de poux soit susceptible, soit résistante au traitement, ainsi que des utilisations dans la fabrication d'un médicament pour traiter ou prévenir une infestation de poux provenant d'une souche susceptible ou résistante au traitement chez un patient humain.

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