Topical bioadhesive formulations

Details Topical bioadhesive formulations Topical bioadhesive formulations

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 9/06 (2006.01) A61K 9/12 (2006.01)

Patent

CA 2594710

The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.

Cette invention concerne des formulations bioadhésives topiques renfermant des mélanges cristallins non liquides de faible viscosité : a) d'au moins un lipide diacyle neutre et/ou d'au moins un tocophérol, b) d'au moins un phospholipide, c) d'au moins un solvant organique de faible viscosité biocompatible renfermant de l'oxygène, dans lesquelles au moins un agent bioactif est dissous ou dispersé dans le mélange de faible viscosité et dans lesquelles la pré-formulation forme ou est capable de former au moins une structure de phase cristalline liquide après contact avec un fluide aqueux. L'invention concerne également un procédé de délivrance d'un agent actif consistant à administrer une pré-formulation de l'invention, une méthode de traitement consistant à administrer une pré-formulation de l'invention et l'utilisation d'une pré-formulation de l'invention dans un procédé de fabrication d'un médicament.

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