A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/14 (2006.01) A61K 9/06 (2006.01) A61K 9/08 (2006.01) A61K 31/437 (2006.01) A61K 47/10 (2006.01)
Patent
CA 2738970
The present invention relates to a composition for improved transdermal drug delivery comprising a drug, a combi-nation of at least two penetration enhancing agents, wherein at least one of the penetration enhancing agents is selected from the group consisting of esters of saturated or unsaturated fatty acids and lower alcohols, and iso-form alcohols; wherein at least one of the penetration enhancing agents is selected from the group consisting of aliphatic diols and triols; and wherein the components are present in a non-aqueous solvent system. A preferred topical composition comprises the active substance imiquimod and the penetration enhancing agents isopropyl myristate and propylene glycol.
La présente invention concerne une composition pour une administration de médicament transdermique améliorée comprenant un médicament, une combinaison dau moins deux agents de pénétration, où au moins un des agents de pénétration est choisi dans le groupe constitué desters dacides gras saturés ou insaturés et dalcools inférieurs et disoformes dalcool; où au moins un des agents de pénétration est choisi dans le groupe constitué de diols et triols aliphatiques; et où les composants sont présents dans un système de solvant non aqueux. Une composition topique préférée comprend la substance active imiquimod et les agents de pénétration myristate disopropyle et propylèneglycol.
Borgstrom Johan
Holmberg Anna
Lindahl Ake
Palsson Christian
Svensson Birgitta
Moberg Derma Ab
Smart & Biggar
LandOfFree
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