A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 8/44 (2006.01) A61K 8/06 (2006.01) A61K 8/39 (2006.01) A61K 8/40 (2006.01) A61K 8/41 (2006.01) A61K 31/13 (2006.01) A61K 31/198 (2006.01) A61K 47/10 (2006.01) A61Q 7/02 (2006.01)
Patent
CA 2455231
Polyethylene glycol ethers of alkyl alcohols having the general formula CH3(CH2)xCH2(OCH2CH2)nOH wherein x is 8 to 20 (of which ceteareth-20, steareth- 20 and steareth-100 are preferred), poloxamer 185, poloxamer 407, N,N-dimethyl dodecylamine N-oxide, and mixtures thereof, are employed to increase follicular delivery and/or follicular residence time of certain water soluble ornithine decarboxylase inhibitors of which 2(difluoromethyl)-2,5-diamino pentanoic acid and its pharmaceutically acceptable salts, hydrates, optical enantiomers and racemic mixture are preferred.
L'invention concerne des esters de polyéthylène glycol d'alcools alkyliques de formule générale CH¿3?(CH¿2?)¿x?CH¿2?(OCH¿2?CH¿2?)¿n?OH, dans laquelle x signifie 8 à 20 (les ceteareth-20, steareth-20 et steareth-100 étant préférés), poloxamer 185, poloxamer 407, N,N-diméthyle dodecylamine N-oxyde, et leurs mélanges. Ces esters servent à augmenter la diffusion folliculaire et/ou le temps de séjour folliculaire de certains inhibiteurs hydrosolubles d'ornithine décarboxylase, l'acide 2(difluorométhyle)-2,5-diamino pentanoïque ainsi que ses sels, hydrates, isomères optiques et mélanges racémiques, ces éléments étant pharmaceutiquement acceptables, étant préférés.
Chou Joyce T.
Parab Prakash
Skinmedica Inc.
Smart & Biggar
Women First Healthcare Inc.
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