Topical compositions containing desthiobiotin and its...

A - Human Necessities – 61 – K

Patent

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A61K 8/49 (2006.01) A61Q 19/08 (2006.01)

Patent

CA 2708538

Topical compositions and methods of use to treat symptoms of reduced skin elasticity are provided comprising desthiobiotin and certain desthiobiotin analogues. These compounds are effective in stimulating LOXL-1 activity and can thus increase elastin remodeling and improve appearance of fine lines, wrinkles, skin sagging and other symptoms of reduced elastin function.

La présente invention concerne des compositions topiques et des procédés d'utilisation afin de traiter des symptômes tels qu'une élasticité réduite de la peau, lesdites compositions comprenant de la desthiobiotine et certains analogues de la desthiobiotine. Ces composés sont efficaces pour stimuler l'activité de LOXL-1 et peuvent induire ainsi une augmentation du remodelage de l'élastine et améliorer l'aspect des ridules, des rides, de l'affaissement de la peau et d'autres symptômes liés à un fonctionnement réduit de l'élastine.

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