Topical corneal analgesia using neurotensin receptor...

A - Human Necessities – 61 – K

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A61K 38/08 (2006.01) A61K 9/70 (2006.01) A61K 38/10 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2680704

A method for administering an ocular analgesic is described. The method includes the steps of providing a topical analgesic that includes a neo-tryptophan-containing neurotensin analog and applying the topical analgesic to the ocular tissue in a dose of about 0.0005 to about 1.2 mg, alternatively about 0.0005 to about 1.0 mg, alternatively about 0.00075 to about 1.0 mg, alternatively about 0.001 mg to about 1.0 mg, alternatively about 0.001 mg to about 0.8 mg, alternatively about 0.001 mg to about 0.7 mg, alternatively about 0.001 mg to about 0.6 mg. Methods of administering a topical analgesic containing a neo-tryptophan-containing neurotensin analog are also described. The topical analgesic can be administered in a patch, gel, lotion, spray, or mist.

Cette invention se rapporte à un procédé d'administration d'un analgésique oculaire. Le procédé comprend les étapes consistant à fournir un analgésique topique comprenant un analogue de la neurotensine renfermant du néo-tryptophane et à appliquer ledit analgésique topique sur le tissu oculaire selon une dose d'environ 0,0005 à environ 1,2 mg, ou d'environ 0,0005 à environ 1,0 mg, ou d'environ 0,00075 à environ 1,0 mg, ou d'environ 0,001 mg à environ 1,0 mg, ou d'environ 0,001 mg à environ 0,8 mg, ou d'environ 0,001 mg à environ 0,7 mg, ou d'environ 0,001 mg à environ 0,6 mg. L'invention concerne également des procédés d'administration d'un analgésique topique contenant un analogue de la neurotensine renfermant du néo-tryptophane. L'analgésique topique peut être administré sous forme de timbre, de gel, de lotion, en spray ou en brumisation.

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