Topical delivery of codrugs

Details Topical delivery of codrugs Topical delivery of codrugs

A - Human Necessities

61

K

A61K 31/573 (2006.01) A61K 9/00 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2467559

The present invention provides pharmaceuticals compositions for topical delivery comprising a suitable carrier and a codrug capable of penetrating, or being transported across, the dermis. The codrug according to the invention comprises a first constituent moiety linked to a second constituent moiety, wherein the second constituent moiety is the same as, or different from, the first constituent moiety. The first and second constituent moieties are so linked that they are easily transported into or across the dermis, into the skin, or into the blood or lymphatic system, and are reconstituted in vivo to form the first and second constituent moieties.

Compositions pharmaceutiques pour administration topique, qui contiennent un excipient approprié et un médicament combiné capable de pénétrer dans le derme ou d'être transporté à travers le derme. Le médicament combiné selon la présente invention contient une première partie constituante liée à une seconde partie constituante, la seconde partie constituante étant identique à la première partie constituante ou différente de cette dernière. Les première et seconde parties constituantes sont liées de manière telle qu'elles sont facilement transportées dans le derme ou à travers le derme, dans la peau, ou dans le sang ou le système lymphatique, et sont reconstituées in vivo pour former les première et seconde parties constituantes.

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