Topical formulation having effects on alleviating...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/196 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/407 (2006.01) A61K 31/415 (2006.01) A61K 31/54 (2006.01) A61K 47/00 (2006.01) A61P 29/00 (2006.01) A61P 31/22 (2006.01)

Patent

CA 2456356

The present invention provides a topical formulation containing NSAID, particularly diclofenac. The topical formulation is particularly useful for alleviating pain/inflammation associated with infection caused by herpes virus, especially herpes simplex virus (HSV) and varicella-zoster virus (VZV). Similar relief can be achieved where diclofenac is replaced with another non-steroidal anti-inflammatory drug (NSALD), which includes, without limitation, etodolac, ketorolac, bromfenac, diflunisal, ibuprofen, fenoprolen, ketoprofen, naproxen, suprofen, meclofenamate, mefenamic acid, piroxicam, meloxicam, indomethacin, sulindac, phenylbutazone, oxyphenbutazone, and tolmetin. The topical formulation is further characterized by its fast relief on pain and/or inflammation associated with infection caused by herpes virus, i.e., a complete relief in no more than seven (7) days after the application of the topical formulation on skins of patients.

La présente invention concerne une composition topique renfermant un anti- inflammatoire non stéroïdien (AINS), le diclofénac. La composition topique est particulièrement utile pour soulager la douleur et l'inflammation dues à l'infection par le virus de l'herpès, en particulier le virus de l'herpès simplex (VHS) et le virus varicelle- zona (VVZ). Un soulagement semblable est obtenu lorsqu'on remplace le diclofénac par un autre AINS, notamment l'étodolac, le kétorolac, le bromfénac, le diflunisal, l'ibuprofène, le fénoprofène, le kétoprofène, le naproxen, le suprofène, l'acide méclofénamique, l'acide méfénamique, le piroxicam, le méloxicam, l'indométacine, le sulindac, la phénylbutazone, l'oxyphenbutazone et la tolmétine. La composition topique est caractérisée par son action rapide pour le soulagement de la douleur et de l'inflammation dues à l'infection par le virus de l'herpès; celles-ci disparaissent complètement dans les sept (7) jours suivant l'application de la composition sur la peau des patients.

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