Topical formulations and methods for elimination and...

A - Human Necessities – 61 – K

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A61K 9/107 (2006.01) A61K 31/7048 (2006.01) A61K 47/44 (2006.01) A61P 33/14 (2006.01)

Patent

CA 2686336

Topical formulations for prophylaxis or elimination of susceptible and treatment resistant head lice wherein the formulation is an aqueous dispersion of an oil phase containing an effective amount of an active ingredient component combining at least one compound that binds to glutamate-gated chloride ion channels and at least one compound that binds to gamma-amino butyric acid (GABA) receptors, dissolved in at least one water- soluble or water-miscible surface active agent with one or more suspending agents and one or more non-ionic surfactants. Also disclosed are methods of using the topical formulations to treat or prevent an infestation of either a susceptible or treatment resistant strain of head lice in a human patient.

L'invention concerne des formulations topiques pour la prophylaxie ou l'élimination de souches de poux susceptibles et résistantes au traitement, la formulation étant une dispersion aqueuse d'une phase huileuse contenant une quantité efficace d'un composant d'ingrédient actif combinant au moins un composé, qui se lie aux canaux ioniques de chlorure activé par un glutamate, et au moins un composé, qui se lie aux récepteurs de l'acide gamma-amino butyrique (GABA), dissous dans au moins un agent tensioactif hydrosoluble ou miscible dans l'eau avec un ou plusieurs agents de suspension et un ou plusieurs agents tensioactifs non ioniques. Des procédés d'utilisation des formulations topiques pour traiter ou prévenir une infestation d'une souche de poux susceptible ou résistante au traitement chez un patient humain sont également décrits.

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