Topical formulations containing as a therapeutic active...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/20 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 31/045 (2006.01) A61K 31/08 (2006.01) A61K 31/201 (2006.01) A61K 31/225 (2006.01) A61K 31/23 (2006.01) A61K 31/231 (2006.01) A61K 47/00 (2006.01)

Patent

CA 2271843

The present invention relates to a method for counteracting infections caused by bacteria, fungi or virus such as Herpes Simplex Virus in skin or mucosal membranes, in particular genital membranes, of a mammal. The method comprises topically administering to the skin or mucosal membrane an effective amount of a formulation comprising a) at least one microbicidal lipid, b) at least one solubilizing agent which keeps the lipid dissolved in the formulation, and optionally c) a gel-forming agent. The formulation used in the method may suitably be in the form of a hydrogel. The microbicidal lipid is preferably a C6-18 fatty acid, such as e.g. lauric acid, or a derivative thereof, e.g. a monoglyceride such as capric acid 1-monoglyceride. The solubilizing agent may suitably be a glycofurol such as the commercially available glycofurol 75. The invention also relates to novel pharmaceutical formulations for use in the method.

La présente invention porte sur un procédé permettant de combattre les infections provoquées par des bactéries, des champignons ou des virus tels que le virus de l'herpès simplex dans des membranes cutanées ou des muqueuses, notamment dans les membranes génitales des animaux. Ce procédé consiste à administrer localement dans une de ces membranes une quantité effective d'une formulation comprenant: a) au moins un lipide microbicide, b) au moins un agent solubilisant qui conserve le liquide dissous dans la formulation, et éventuellement c) un agent gélifiant. La formulation utilisée dans ce procédé peut se présenter sous forme d'un hydrogel. Le lipide microbicide est de préférence un acide gras en C¿6-18? tel que l'acide laurique ou un dérivé de celui-ci, p.ex. un monoglycéride tel qu'un monoglycéride 1 d'acide caprique. L'agent solubilisant peut être un glycofurol tel que le glycofurol 75 disponible dans le commerce. L'invention porte également sur de nouvelles formulations pharmaceutiques destinées à être utilisée dans ce procédé.

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