Topical gel delivery system

Details Topical gel delivery system Topical gel delivery system

A - Human Necessities

61

K

A61K 31/7056 (2006.01) A61K 31/203 (2006.01) A61K 31/573 (2006.01) A61K 31/58 (2006.01) A61K 47/32 (2006.01) A61P 17/10 (2006.01)

Patent

CA 2417646

A topical aqueous gel composition is provided that has a viscosity of less than about 15,000 cP and a pH of about 3.0 to 9.0 for treating a skin disorder in a human subject. The composition consists essentially of (a) a therapeutically- effective amount of at least one compound useful for treating such a disorder, (b) a hydrophilic pharmaceutically-acceptable, polymer material such as a lightly cross-linked polyacrylic acid polymer compatible with the compound, (c) a pharmaceutically-acceptable base to adjust pH, (d) optionally a water miscible solvent, (e) optionally a preservative, (f) water, and (g) optionally an oil phase component and a suitable surfactant. The composition is useful for treating an inflammatory skin disorder, acne, or rosacea. The low viscosity composition has an advantage of being administered more accurately when combined with a container that administers the composition as drops.

L'invention porte sur une composition d'une viscosité de moins de 15,000 cP et d'un pH d'environ 3,0 à 9,0 destinée au traitement des affections de la peau. Ladite composition comporte essentiellement: (a) une quantité à effet thérapeutique d'au moins un composé apte à traiter lesdites affections, (b) un polymère pharmacocompatible d'acide polyacrylique faiblement réticulé compatible avec le composé, (c) facultativement un solvant miscible à l'eau, (d) facultativement un agent conservateur, (e) facultativement un composant en phase huileuse et un tensio-actif approprié, et (f) de l'eau. La composition; qui s'utilise pour le traitement d'inflammations de la peau, telles que l'acné, ou la kératite rosacée, présente de par sa faible viscosité l'avantage de pouvoir s'administrer de manière plus précise lorsqu'associée à un récipient la distribuant sous forme de gouttes.

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