Topical mecamylamine formulations for ocular administration...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 31/13 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2633655

Provided are methods, pharmaceutical formulations and kits thereof for the treatment and/or prevention of conditions mediated by neovascularization, abnormal angiogenesis, vascular permeability, or combinations thereof, of posterior and/or anterior tissues and fluids of the eye, including conditions associated with proliferative retinopathies, for example, diabetic retinopathy, age- related maculopathy, retinopathy of prematurity, retinopathy associated with macular edema, or retinopathy associated with sickle cell disease, using the topical administration of mecamylamine or a pharmaceutically acceptable salt thereof to the eye. Methods of preparing the pharmaceutical formulations are also provided.

La présente invention concerne des procédés, des préparations pharmaceutiques et des kits de ces préparations destinés au traitement et/ou à la prévention d'états induits par néovascularisation, angiogenèse anormale, perméabilité vasculaire ou une combinaison de ces pathologies, des tissus et des fluides postérieurs et/ou antérieurs de l'oeil, notamment des états associés à des rétinopathies prolifératives, par exemple, à la rétinopathie diabétique, à la maculopathie liée à l'âge, à la rétinopathie de prématurité, à la rétinopathie associée à l'oedème maculaire, ou à la rétinopathie associée à une drépanocytose, utilisant l'administration topique de mécamylamine ou un sel de ce composé pharmaceutiquement acceptable sur l'oeil. Cette invention concerne aussi des procédés de préparation de ces préparations pharmaceutiques.

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