Topical medicinal pressurized aerosol compositions and...

A - Human Necessities – 61 – K

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A61K 9/12 (2006.01)

Patent

CA 2027952

22749-365 D.N. 1080A ABSTRACT Topical medicinal pressurized aerosol compositions and method of preparation, method of use and article of manufacture thereof especially wherein the topical medicament is mafenide or a pharmaceutically acceptable acid addition salt thereof, most especially mafenide acetate, and especially for treatment of burns are disclosed. The aerosol compositions consist essentially of by weight/weight from about 0.1% to about 15% of a topical medicament or a mixture of two or more topical medicaments, from about 3% to about 20% of a liquified propellant or a mixture of two or more liquified propellants, from about 20% to about 80% of an aqueous vehicle, and from about 0.1% to about 10% of a nonionic polyoxyethylene surfactant or a mixture of two or more nonionic polyoxyethylene surfactants each having at least 80% by molecular weight of oxyethylene units, the composition being dischargeable from an aerosol dispenser as a spray that forms a stable foam on the application site.

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