Topical parasiticide formulations and methods of treatment

Details Topical parasiticide formulations and methods of treatment Topical parasiticide formulations and methods of treatment

A - Human Necessities

61

K

A61K 31/167 (2006.01) A61K 9/107 (2006.01) A61K 31/365 (2006.01) A61K 31/4184 (2006.01) A61K 31/7048 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2504197

Aqueous micellar formulations for topical administration of benzimidazoles or salicylanilides with macrocyclic lactones to livestock for the control of endo~and ecto-parasites, comprising a first active agent selected from water insoluble benzimidazoles, salicylanilides and active derivatives or salts thereof, in combination with a second active agent selected from macrocyclic lactones or active derivatives or salts thereof, and also comprising, per litre of formulation: from about 100 to about 400g veterinary acceptable surfactant(s); from about 200 to about 750g veterinary acceptable water- miscible solvent(s); and from about 50 to about 350g water, as well as methods for dosing livestock with such formulations, and methods for controlling and/or preventing diseases or parasite infection in livestock.

L'invention concerne des formulations micellaires aqueuses destinées à l'administration topique au bétail de benzimidazoles ou salicylanilides et de lactones macrocycliques pour le contrôle d'endo-parasites et ecto-parasites. Ces formulations contiennent un premier agent actif sélectionné parmi les benzimidazoles, salicylanilides insolubles dans l'eau et leurs dérivés actifs ou sels, et associé à un deuxième agent actif sélectionné parmi des lactones macrocycliques ou leurs dérivés actifs ou sels, et contenant également, par litre de formulation : 100 à 400 g environ de tensio-actifs vétérinairement acceptables, 200 à 750 g environ de solvants miscibles à l'eau et vétérinairement acceptables et 50 à 350g environ d'eau. L'invention concerne également des procédés de posologie de telles formulations pour le bétail et des procédés de contrôle et/ou de prévention de maladies ou infections parasitaires du bétail.

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