Topical, periocular, or intraocular use of tocotrienols for...

Details Topical, periocular, or intraocular use of tocotrienols for... Topical, periocular, or intraocular use of tocotrienols for...

A - Human Necessities

61

K

A61K 31/355 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2760357

A method for preventing, reducing, ameliorating or treating ophthalmic disorders associated with neurodegenerative diseases or trauma, comprising the topical, periocular, or intraocular application of an ophthalmic formulation comprising a therapeutically effective amount of one or more ophthalmic agents selected from the group consisting of alpha-tocotrienol, beta- tocotrienol, gamma-tocotrienol, delta-tocotrienol, or esters or mixtures thereof is disclosed. Use of tocotrienols for the prevention, reduction, amelioration or treatment of ophthalmic disorders that are, or that are associated with, mitochondrial diseases is also discussed. Topical ophthalmic formulations comprising tocotrienols are also discussed.

L'invention concerne un procédé de prévention, de réduction, de soulagement ou de traitement de troubles ophtalmiques associés à des maladies neurodégénératives ou à un trauma, le procédé comprenant l'application topique, périoculaire ou intraoculaire d'une formulation ophtalmique comprenant une quantité thérapeutiquement efficace d'un ou plusieurs agents ophtalmiques choisis dans le groupe constitué par l'alpha-tocotriénol, le bêta-tocotriénol, le gamma-tocotriénol, le delta-tocotriénol ou des esters ou des mélanges de ceux-ci. L'invention concerne également l'utilisation de tocotriénols pour la prévention, la réduction, le soulagement ou le traitement de troubles ophtalmiques qui sont des maladies mitochondriales ou qui sont associés à de telles maladies. L'invention concerne également des formulations ophtalmiques topiques comprenant des tocotriénols.

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