Topical pharmaceutical composition comprising a cholinergic...

A - Human Necessities – 61 – K

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A61K 31/55 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 31/27 (2006.01) A61K 31/554 (2006.01) A61K 31/573 (2006.01)

Patent

CA 2281755

A cholinergic agent and/or a calcium channel blocker is administered locally to the anus for the treatment of benign anal disorders, in particular anal fissures and haemorrhoids. The agents induce a reduction in the mean and resting pressure, thereby assisting in the healing of the anal fissures and haemorrhoids. Particularly preferred active agents are bethanechol and diltiazem, more particularly a combination thereof.

L'invention concerne un agent cholinergique et/ou un inhibiteur calcique que l'on administre localement sur l'anus pour traiter des affections anales bénignes, en particulier les fissures anales et les hémorroïdes. Ces agents provoquent une diminution de la pression moyenne et au repos, contribuant ainsi à la guérison des fissures anales et des hémorroïdes. Les agents actifs particulièrement préférés sont le béthanéchol et le diltiazem, plus particulièrement, une combinaison des deux.

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