Topical pharmaceutical formulations and methods of treatment

Details Topical pharmaceutical formulations and methods of treatment Topical pharmaceutical formulations and methods of treatment

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2413699

In certain embodiments, the present invention is directed to a pharmaceutical formulation for topical administration on a mammal, comprising a unit dose of a therapeutically effective amount of a therapeutic agent and a pharmaceutically acceptable carrier medium therefor, said formulation being solid at ambient temperature and having a softening point of not higher than 35 ~C, such that when the formulation is placed in continuous contact with the skin of a mammalian patient, it is softened to a consistency to effect substantial application of the unit dose of said therapeutic agent onto a desired skin area of the mammalian patient within a time period of less than 10 minutes.

Selon certains modes de réalisation, Cette invention concerne une formulation pharmaceutique pour administration topique sur un mammifère, comprenant une dose unitaire efficace d'un agent thérapeutique et d'un excipient acceptable au plan pharmaceutique. Ladite formulation se trouve à l'état solide à la température ambiante, avec un point de ramollissement correspondant à une température de 35 ·C maximum. Ainsi, lorsqu'elle est placée en contact continu sur la peau d'un patient mammifère, cette formulation se ramollit jusqu'à un point autorisant une application substantielle de la dose d'agent thérapeutique en un laps de temps de 10 minutes maximum.

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