Topical transdermal treatments

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 29/147 (2006.01) A61K 31/045 (2006.01) A61K 31/355 (2006.01) A61K 31/60 (2006.01) A61K 36/185 (2006.01) A61P 31/22 (2006.01) A61P 35/00 (2006.01) C07C 33/025 (2006.01)

Patent

CA 2333903

Jojoba alcohol, an oily liquid at moderate ambient temperatures, is readily absorbed by human skin where it relieves irritation and inhibits the formation of lesions caused by viruses. The inhibitory action is applicable to enveloped viruses which express as sores at dermal surfaces in human. When applied topically to an incipient herpes episode, it will quickly penetrate the epidermis to the subdermal cells and suppress viral replication which leads to inflammation and the formation of blisters on the face, genital and other skin and mucosal areas. Compositions of low molecular weight organic acids in jojoba alcohol enhance antiviral activity. Jojoba alcohol is a transdermal delivery system for these virucidal acids and other pharmacologically active agents. Topically applied jojoba alcohol is non-toxic to small animals and humans. Jojoba alcohol prepared here by chemical hydrogenolysis of jojoba oil is a mixture principally of mono unsaturated alcohols with 14 to 24 linear carbons in the chain.

L'alcool de jojoba, liquide aux températures ambiantes modérées, est facilement absorbé par la peau dont il soulage l'irritation tout en empêchant la formation de lésions d'origine virale. Son action inhibitrice agit sur les virus à enveloppe qui produisent chez l'homme des lésions cutanées. Appliqué localement à un début d'herpès, il pénètre rapidement l'épiderme jusqu'aux cellules sous-cutanées et empêche la reproduction des virus responsables de l'inflammation et de la formation de vésicules sur la figure, les parties génitales et autres zones de la peau et des muqueuses. Les acides organiques de faible poids moléculaire de l'alcool de jojoba en renforcent l'activité antivirale. Ce dernier, qui constitue un système transdermique d'administration de ces acides virucides et d'autres agents pharmacologiquement actifs, n'est par ailleurs pas toxique pour les petits animaux ni pour l'homme en application locale. L'alcool de jojoba, qui se prépare par hydrogénolyse chimique de l'huile de jojoba est un mélange comprenant principalement des alcools monoinsaturés à chaîne à 14 à 24 carbone linéaires.

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