Topical use of valproic acid for the prevention or treatment...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/19 (2006.01) A61K 31/20 (2006.01) A61K 31/44 (2006.01) A61K 31/4436 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2531101

The present invention relates to a topically applicable formulation containing Valproic Acid or a derivative thereof which can be used alone or in combination with topically applicable formulations of retinoids or of nuclear receptor ligands, or of chemotherapeutic agents (e.g. 5-Fluorouracil). The formulation is useful for the topical treatment of cancerous skin disorders, such as Basal Cell Carcinoma, Squamous Cell Carcinoma, Keratoakantoma, Bowen Disease, cutaneous T-Cell Lymphoma and also for the topical treatment of pre- malignant lesions, and of inflammations of the skin and/or mucosa. The invention also relates to the use of this topically applicable formulation for the protection from UV light and for the treatment of sun burn. The invention includes the use of VPA for the manufacture of a clinically used medicament for the topical treatment of the human diseases listed above.

La présente invention concerne une préparation à application topique qui contient de l'acide valproïque ou un dérivé de celui-ci et qui peut être utilisée seule ou combinée à des préparations à application topique de rétinoïdes, de ligands de récepteur nucléaire ou d'agents chimiothérapeutiques (par ex. 5-fluorouracile). La préparation selon cette invention est utilisée pour le traitement topique de problèmes de peau atteinte d'un cancer, tels que des carcinomes basocellulaire, des carcinomes squameux, des kérato-acanthomes, la maladie de Bowen et des lymphomes T cutanés, et pour le traitement topique de lésions prémalignes et d'inflammations de la peau et/ou des muqueuses. La présente invention concerne également l'utilisation de cette préparation à application topique pour une protection anti UV et pour traiter des coups de soleil. Cette invention concerne l'utilisation d'acide valproïque pour produire un médicament à usage clinique pour le traitement topique des maladies humaines susmentionnées.

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