Topically active ocular benzothiazole sulfonamide carbonic...

Details Topically active ocular benzothiazole sulfonamide carbonic... Topically active ocular benzothiazole sulfonamide carbonic...

C - Chemistry, Metallurgy

07

D

C07D 277/80 (2006.01) A61K 31/425 (2006.01)

Patent

CA 2095050

2095050 9114682 PCTABS00007 This invention is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R6 is hydrogen or lower alkyl; each R1 is hydrogen, lower alkyl, halogen, nitro, trihaloalkyl, lower alkoxy, formyl, lower alkanoyl, loweralkylamino or diloweralkylamino; Y is (II) or (III); X is O, S or NR5; R2 is OR7 or NR7R8; each R3 and R4 are independently hydrogen or lower alkyl; R5, R7 and R8 are independently hydrogen or lower alkyl; n is 0-3 and m is 0-6. These compounds are useful for treating glaucoma or assessing corneal function in mammals.

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