Topically active steroidal anti-inflammatory agents

Details Topically active steroidal anti-inflammatory agents Topically active steroidal anti-inflammatory agents

C - Chemistry, Metallurgy

07

J

260/15, 167/197,

C07J 5/00 (2006.01) A61K 31/56 (2006.01) A61K 31/57 (2006.01) A61K 31/58 (2006.01) C07J 7/00 (2006.01) C07J 61/00 (2006.01) C07J 71/00 (2006.01) C07J 73/00 (2006.01)

Patent

CA 2000369

ABSTRACT OF THE DISCLOSURE Introduction of a C-12 substituent and especially a .beta. C-12 substituent into glucocor- ticoids improves their usefulness as topical antiinflammatories by increasing their topical activity relative to their systemic activity, thus- reducing systemic side effects such as adrenal suppression.

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