Topically applied clotting material

Details Topically applied clotting material Topically applied clotting material

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/70 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01) A61L 15/16 (2006.01) A61L 15/44 (2006.01) A61P 7/04 (2006.01)

Patent

CA 2399870

A composition, system, articles and method for the enhancement of clotting in wounds with extravascular blood flow, especially where the surface of the tissue has been broken is described. The system consists of biotolerable, porous particulates applied to the surface of a wound with liquid blood thereon. The porous nature of the particulate material, either free-flowing or packaged or restrained on or in a surface, enhances clotting. Chemical or biochemical agents, such as additional clotting agents, therapeutic agents, antibiotics, clot strengthening agents (such as fibrous structural materials), and the like may optionally be included on, with or within the porous particles. The particles may comprise such diverse materials as organics, metallics, inorganics, ceramics, and the like, both natural and artificial. It is generally preferred that the pore size distribution lies within a general range, and this range may vary from animal to animal and condition to condition, but generally falls within about 0.5 to 1000 micrometers or 3,000 to 200,000 Daltons.

L'invention concerne une composition, un système, des articles et un procédé destinés à améliorer la coagulation de blessures à saignement extravasculaire, et plus particulièrement lorsque la surface du tissu est abîmée. Ce système comprend des particules poreuses biotolérables appliquées sur la surface d'une blessure qui saigne. La nature poreuse de la matière particulaire, qu'elle soit à empreinte fluide, emballée ou fixée sur ou dans une surface, permet d'améliorer la coagulation. Des agents chimiques ou biochimiques, tels que des agents coagulants supplémentaires, des agents thérapeutiques, des antibiotiques, des agents renforçateurs de coagulation (telles que des matières structurelles fibreuses), et analogues peuvent éventuellement être ajoutés sur les particules poreuses, avec celles-ci, ou à l'intérieur de celles-ci. Ces particules peuvent comprendre différentes matières, telles que des matières organiques, métalliques, inorganiques, céramiques, et analogues, naturelles ou artificielles. De préférence, la distribution de la taille des pores se situe dans une marge générale, et cette marge peut varier d'un animal à un autre et d'un état à un autre, mais se situe généralement entre 0,5 et 1000 micromètres environ ou entre 3000 et 200 000 daltons.

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