C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/44 (2006.01) A61K 39/385 (2006.01) C07H 9/04 (2006.01) C07H 13/00 (2006.01) C09B 57/00 (2006.01) G01N 33/53 (2006.01) G01N 33/532 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2239224
The present invention provides a topiramate immunoassay and reagents for use in the immunoassay. In particular, topiramate is derivatized at the sulfamate moiety or the 9-carbon or 10-carbon methyl group of topiramate to add a label bound directly or through a linking group for use as a tracer (competitive analyte analog) or to add a linking group bound to a carrier for use as an immunogen to induce anti-topiramate antibodies. Immunoassay methods and kits are also provided.
L'invention concerne un dosage immunologique de topiramate, ainsi que des réactifs conçus pour être utilisés dans ce dosage immunologique. Le topiramate est dérivé au niveau de la fraction sulfamate ou du groupe 9-carbone ou 10-carbone méthyle, en vue de l'addition d'un marqueur par liaison directe ou par l'intermédiaire d'un groupe de liaison, utilisé en tant que traceur (analogue d'analyte concurrent), ou de l'addition d'un groupe de liaison lié à un véhicule, à utiliser en tant qu'immunogène servant à provoquer l'apparition d'anticorps anti-topiramate. L'invention concerne également des techniques et des trousses de dosage immunologique.
Cawley Daniel B.
Maryanoff Bruce E.
Sorgi Kirk L.
Stenglein Kenneth J.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Oxis International Inc.
Seradyn Inc.
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