Topoisomerase inhibitors

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 9/06 (2006.01) A61K 31/7056 (2006.01) A61P 35/00 (2006.01) C07H 19/23 (2006.01)

Patent

CA 2424971

The present invention relates to novel N12, N13-bridged sugar derivatives of indolylopyrrolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.

L'invention concerne des nouveaux dérivés glycosides, pontés en N12, N13, d'indolylopyrrolocarbazoles; elle concerne également des formulations pharmaceutiques de ces dérivés, lesquelles possèdent une activité à l'égard des topo-isomérases-I et sont donc utiles pour inhiber la prolifération de cellules tumorales.

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