Topoisomerase-targeting agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 491/056 (2006.01) A61K 31/4741 (2006.01) A61P 17/06 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2510337

The invention provides compounds of formula I or formula (II), wherein: the bond represented by --- is a single bond or a double bond, and R1-R5, X, and Y have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula (I or II), processes for preparing compounds of formula (I or II), intermediates useful for preparing compounds of formula (I or II), and therapeutic methods for treating cancer and other topoisomerase related conditions using compounds of formula (I or II).

Cette invention, qui a trait à des composés correspondant à la formule (I) ou à la formule (II), formules dans lesquelles la liaison figurée par --- représente une liaison unique ou double et R¿1?- R¿5?, X, Y ayant les significations définies dans le descriptif, concerne également leurs sels acceptables du point de vue pharmaceutique. Elle porte, en outre, sur des compositions pharmaceutiques contenant un composé correspondant à la formule (I ou II), sur des procédés permettant de préparer ces composés (de formule I ou II) ainsi que des intermédiaires entrant dans leur préparation et sur des méthodes thérapeutiques utilisant ces composés (de formule I ou II) et destinées à traiter le cancer ainsi que d'autres états pathologiques liés aux topoisomérases.

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